Our Commitment to Quality
Each of our ingredients has been chosen based on clinical research studies demonstrating superior efficacy. Recover-E supports healthy adrenal function and renews cellular energy with antioxidants plus adaptogenic herbs from Ayurvedic & Chinese Medicine. See the list of ingredients and their effects, along with links to published studies below.
Vitamin C – as Ascorbic Acid and as Sodium Ascorbate
Let’s start with a dietary staple, vitamin C. Essential for cellular repair, our body’s biggest reserve of vitamin C is in our adrenal glands. Without adequate vitamin C, our adrenals struggle to produce the right amount of cortisol for our daily needs.
Cortisol is the hormone responsible for waking in the morning, so while an excess of it is bad for our health, the right amount is essential. In the earlier stages of burnout, our adrenals tend to be overactive, leaving us with elevated cortisol levels and, in turn, a suppressed immune response. In the later stages of burnout, our adrenals need all the support they can get, and vitamin C plays a key role in this. Vitamin C is useful at every stage of burnout in supporting the immune system as well as our adrenal function.
Vitamin C has been studied for its role in aiding improvement with many conditions, ranging from neurodegenerative conditions such as Alzheimer’s, to post-chemotherapy recovery.
Some studies on the role of vitamin C:
- Heo JH, Hyon-Lee, Lee KM. The possible role of antioxidant vitamin C in Alzheimer’s disease treatment and prevention. Am J Alzheimers Dis Other Demen. 2013:28(2):120-5. http://journals.sagepub.com/doi/abs/10.1177/1533317512473193
- Paschalis, V; Theodorou, A. A; Kyparos, A. et al, 2016. Low vitamin C values are linked with decreased physical performance and increased oxidative stress: reversal by vitamin C supplementation. European Journal of Nutrition, Vol. 55, Issue 1, pp 45-53.
- Peters, E.M; Anderson, R; Nieman, D.C; Fickl, H; Jogessar, V. Vitamin C Supplementation Attenuates the Increase in Circulating Cortisol, Adrenaline and Anti-Inflammatory Polypeptides Following Ultramarathon Running. Department of Physiology, School of Medical Sciences, Faculty of Medicine. http://www.dizzy.com/wp-content/uploads/Vitamin-C-Supplementation-Attenuates-the-Increases-in-Circulating-Cortisol-1.pdf
Vitamin E – as Mixed Tocopherols
Vitamin E is the body’s most important fat-soluble antioxidant, assisting with maintaining the integrity of cellular tissues. Vitamin E is especially useful for post-exercise recovery, protecting the eyes, and preventing a host of conditions from diabetes to neurodegenerative conditions.
Studies have shown vitamin E, specifically Tocopherols, to be beneficial in fighting a wide range of inflammatory diseases. We have included Tocopherols in Recover-E to make this a bio-available supplement, meaning it can be readily absorbed by the body.
Some studies on the role of vitamin E as Tocopherols:
- Jialal I, Devaraj S, Venugopal SK. Oxidative stress, inflammation, and diabetic vasculopathies: the role of alpha tocopherol therapy. Free Radic Res. Dec2002;36(12):1331-6. https://www.tandfonline.com/doi/abs/10.1080/1071576021000038531
- Kanchi, M. M; Shanmugam, M. K; Rane, G; Sethi, G; Kumar, A. P. Tocotrienols: the unsaturated sidekick shifting new paradigms in vitamin E therapeutics. Drug Discovery Today. Vol. 22, Issue 12, December 2017, Pages 1765-1781. https://www.sciencedirect.com/science/article/pii/S135964461730137X
- Shen, L; Ji, H.F. Vitamin E: supplementation versus diet in neurodegenerative diseases. Trends in Molecular Medicine. August 2012; 18(8): 443-5 https://www.ncbi.nlm.nih.gov/pubmed/22575671
Vitamin B3 (Niacin) – as Niacinamide
Niacinamide has been used to treat Type 1 diabetes due to its effects on the product of energy from carbohydrates. It’s also understood to reduce bad cholesterol while increasing good cholesterol.
Although its early days in terms of studies with heart attack patients, successful reduction in mortality for heart attack when treated with Niacinamide.
Vitamin E is a powerful antioxidant – something our bodies need more of when we are responding to long-term stress. Oxidative stress at the cellular level is associated with a host of stress-induced illnesses and conditions. Reduced antioxidant defense directly affects synaptic activity and neurotransmission in neurons leading to cognitive dysfunction. We’ve included Niacinamide in our Recover-E formula to assist your immune system and antioxidant defense systems in minimizing the cognitive effect of burnout.
Common dietary sources of both niacin, and its chemical precursor tryptophan are meat and dairy. Therefore vitamin B3 supplementation is especially encouraged for vegetarians and vegans.
Some studies on the effects of Niacinamide:
- Tonnies, R; Trushina, E. Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease. Journal of Alzheimer’s Disease. Vol. 57, no. 4, pp. 1105-1121, 2017. https://content.iospress.com/articles/journal-of-alzheimers-disease/jad161088
- Gugliandolo, A; Bramanti, P; Mazzon, E. Role of Vitamin E in the Treatment of Alzheimer’s Disease: Evidence from Animal Models. Int. J. Mol. Sci. 2017, 18 (12), 2504. http://www.mdpi.com/1422-0067/18/12/2504
- Mullen, K; Williams, M.A et al. Alzheimer’s & Dementia: Translational Research & Clinical Interventions. Vol. 3, Issue 3, September 2017, Pages 432-439. https://www.sciencedirect.com/science/article/pii/S2352873717300446
Vitamin B5 (Pantothenic Acid) – as Calcium Pantothenate
This is a very important nutrient for adrenal support, assisting in steroid hormone synthesis, so essential for burnout recovery. Vitamin B5 is also indicated for people recovering from surgery or intense physical activity, in part due to its association with reducing inflammation.
Also important for energy metabolism, B5 enhances the release of energy from carbohydrates. It is essential for the production of acetylcholine, the neurotransmitter most associated with skeletal muscle movement. It keeps us moving and energized.
Some studies on the effects of vitamin B5:
- Gominak, S.C. Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a “pro-inflammatory” state associated with atherosclerosis and autoimmunity. Medical Hypothesis. Vol. 94, Pages 103-107, September 2016. https://www.sciencedirect.com/science/article/pii/S0306987716303504
- Homan, J; Schijns, W; et al. Treatment of Vitamin and Mineral Deficiencies After Biliopancreatic Diversion With or Without Duodenal Switch: a Major Challenge. Obesity Surgery, January 2018, Vol. 28, Issue 1, pp 234-241. https://link.springer.com/article/10.1007/s11695-017-2841-0
Vitamin B6 – as Pyridoxal 5 Phosphate
Pyridoxal 5’-phosphate is the metabolically active coenzyme form of vitamin B6, chosen for its bioavailability. Vitamin B6 deficiency is one of the most common nutritional deficiencies, which is partially due to large amounts being lost during cooking and food processing.
Vitamin B6 is also an inflammation-fighter, and studies show benefits to cardiovascular health. It is essential for red blood cell and niacin production. It’s also requires for neurotransmitter production, which is crucial for people experiencing burnout.
When carbohydrates are stores in our liver, they take the form of glycogen. Vitamin B6 allows glycogen to be converted to glucose, giving us a needed energy boost.
Some studies on the effects of vitamin B6:
- Lotto, V; Choi, S.W; Friso, S. Vitamin B6: a challenging link between nutrition and inflammation in CVD. The British Journal of Nutrition. 106 (2): 183-95, July 2011. https://www.ncbi.nlm.nih.gov/pubmed/21486513
- Wyatt, K.M; Dimmock, P.W; Jones, P.W. et al. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. British Medical Journal. 318( 7195):1375-1381, May 1999. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27878/
Vitamin B12 – as Methylcobalmin
Vitamin B12 is crucial for neurological health. It plays a key role in the metabolism of cells, including our brain cells and our red blood cells. Many of us are deficient in B12 due to our diets. Deficiency can manifest as anemia, fatigue, depression, confusion, pain and skin sensitivity. It can also show up as a lack of appetite – unhelpful when we need to be getting more nutrients!
When we are extra tired and needing help to get going again, replenishing our B12 is a smart move. If you are following a vegetarian and vegan diet then supplementing B12 is strongly advised, as it is not present in meat and dairy free diets.
Some studies on the effects of vitamin B12:
- Koning, E.J; van der Zwaluw, N.L; van Wijngaarden, J.P. et al. Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, and RCT. Nutrients, 8, 748, 2016. https://books.google.co.uk/books?hl=en&lr=&id=eP9hDwAAQBAJ&oi=fnd&pg=PA142&dq=b12+&ots=RoudpW8Ggd&sig=KfwFLvSgSobhJMhdghIxSpE_egg#v=onepage&q=b12&f=false
- Kumar, N. Neurologic presentations of nutritional deficiencies. Neurologic Clinics, 28(1): 101-70, February 2010. https://www.ncbi.nlm.nih.gov/pubmed/19932379
- Yajnik, C.S; Lubree, H.G; Thuse, N.V. et al. Oral vitamin B12 supplementation reduces plasma total homocysteine concentration in women in India. Asia Pac Journal of Clinical Nutrition 2007;16(1):103-9. https://www.ncbi.nlm.nih.gov/pubmed/17215186
Vitamin A – as Mixed Carotenoids
Vitamin A is an antioxidant and important in eye health and immunity. Our main dietary sources of vitamin A are meat and dairy products, so supplementing is important for vegans and vegetarians.
Vitamin A is also essential for bone and soft tissue health, including tooth enamel and all epithelial cells which cover the surface of our skin and many other organs.
Some studies on the role of carotenoids:
- Akuffo, K. O; Nolan, J. M; Howard, A. N. et al, 2015. Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular degeneration. Eye, 29, 902-912. https://www.nature.com/articles/eye201564
- Grether-Beck, S; Marini, A; Jaenicke, T. et al. 2016. Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double‐blinded, placebo‐controlled, crossover study. British Journal of Dermatology, 23rd September 2016. https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.15080
Ashwagandha (Withania somnifera) Root Extract
Ashwagandha, also known as Indian ginseng and winter cherry, has been an important herb in Ayurvedic medicine for over 3000 years. It is used for treating stress, nervousness and other symptoms of overwork.
Ashwagandha contains withanoids which are adaptogenic steroidal alkaloids known for enhancing mental and physical performance, and also fighting fatigue and stress. These compounds are similar in structure to steroid hormones and precursors that act on the adrenal cortex, hence their importance in recovery from adrenal fatigue and burnout.
Some studies on the uses of Ashwagandha:
- Rani, G; Kaur, K; Wadha, R; Kaul, S. C; Nagpal, A. Evaluation of the anti-genotoxicity of leaf extract of Ashwagandha. Food and Chemical Toxicology, January 2005, 43(1): 95-8. https://www.ncbi.nlm.nih.gov/pubmed/15582200
- Tohda, C; Kuboyama, T; Komatsu, K. Dendrite extension by methanol extract of Ashwagandha (roots of Withania somnifera) in SK-N-SH cells. Neuroreport, June 2000, 11(9): 1981-5. https://www.ncbi.nlm.nih.gov/pubmed/10884056
Eleuthero (Acanthopanax senticosus) Stem and Root Extract (0.8% Eleutherosides)
Eleuthero, also known as Siberian ginseng is one of the more commonly known herbal remedies for ADHD. Eleuthero is also believed by herbalists to boost the immune system and interact with the body to assist in reacting to stress.
The adaptogenic herb is great if you struggle with focus and attention, especially during times of stress. It has even been studied for its potential to help with breast cancer.
Some studies on the uses of Eleuthero:
- Akhondzadeh, S. Attention-Deficit/Hyperactivity Disorder and Herbal Medicine: An Evidence Based Approach. Journal of Medicinal Plants, Volume 1, Issue 65, 2018.
- Marcos, S; Larumbe, E; Alkhatib, Naclerio, F. Effectiveness of multi-ingredient supplement on substrate utilisation, perception of hunger, mood state and rate of perceived exertion (RPE) at rest and during exercise. Journal of the International Society of Sports Nutrition, 2015. 12 (Suppl 1): P42. https://jissn.biomedcentral.com/articles/10.1186/1550-2783-12-S1-P42
Licorice (Glycyrrhiza glabra) Root Extract (20% Glycyrrhizic Acid)
Glycyrrhiza glabra, another adaptogenic herb, has anti-inflammatory and immune-boosting properties. It is linked to female hormone regulation and calming IBS symptoms.
Its use is indicated for adrenal fatigue and a range of other conditions, varying from leaky gut to the common cold.
Some studies on the uses of Glycyrrhiza glabra:
- Adrenal Fatigue Solution, 2018. How To Use Licorice Root For Adrenal Fatigue. https://adrenalfatiguesolution.com/licorice-root-adren
- Davis, E. A; Morris, D. J. Medicinal uses of licorice through the millennia: the good and plenty of it. Molecular and Cellular Endocrinology. 78 (1991) 1-6. http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.554.1916&rep=rep1&type=pdf
- Pandey, S; Verma, B; Arya, P. A review on constituents, pharmacological activities, and medicinal uses of Glycyrrhiza Glabra. Universal Journal of Pharmaceutical Research. Volume 2, Issue 2, 2017. http://ujpr.org/index.php/journal/article/view/41
Although official magnesium (Mg) dietary reference intakes are open to question, a significant number of adults likely have intakes that are in the range of 50%-99% of the requirement.
Human studies have found that a lack of dietary magnesium is related to serum or plasma C-reactive protein (CRP). Individuals with apparently deficient magnesium intakes have an increased likelihood of low serum or plasma CRP, which is considered an indicator of chronic inflammatory stress that increases the risk for chronic disease.
In addition, elevated serum or plasma CRP in individuals with chronic disease is decreased by magnesium supplementation, which suggests that magnesium decreases the risk for chronic disease.
Magnesium supplementation is helpful for a wide range of conditions such hypertension, ischemic heart disease, stroke, metabolic syndrome, diabetes, migraine and IBS. It has also been studied as an aid for people experiencing mild to moderate depression.
Some studies on the roles of magnesium:
- Dibaba, D. T; Xun, P; Song, Y. et al, 2017. The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition, Volume 106, Issue 3, 1 September 2017, Pages 921–929.
- Tarleton, E. K; Littenberg, B; MacLean, C.D. et al 2017. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS ONE 12(6): e0180067.