Uplift Me ingredients are chosen based on medical research
5-HTP, an amino acid, is the chemical precursor to serotonin, which is hugely important for the brain. Presence of serotonin increases levels of dopamine and norepinephrine, which in turn have their own important roles in the maintaining our mood and providing a counterbalance to stress.
Serotonin is known to influence the synthesis of melatonin, essential for sleep, stable mood, reduced pain and even reduced appetite.
It is widely reported that low levels of serotonin can cause symptoms of depression and anxiety, and can contribute to sleep problems. Serotonin is also reported to reduce migraine headaches.
Some studies on the role of 5HTP:
- Pinocchioro LM, Nahmod VE, Launay JM. Melatonin biosynthesis and metabolism in peripheral blood mononuclear leukocytes. Biochem J. 1991;280(pt 3):727-731. http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1130514&blobtype=pdf
- Nagata, E; Shibata, M; Hamada, J; Shimizu, T; Katoh, Y; Gotoh, K; Suzuki, N. Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period. Headache. 2006;46(4):592-6.
- Rechenberg, K. 2015. Nutritional Interventions in Clinical Depression. Clinical Psychological Science.
Mucuna Pruriens (98% L-Dopa) and L-Tyrosine
L-Tyrosine is the chemical precursor to L-Dopa, which is the chemical precursor to dopamine. So long as you are not already prescribed L-Dopa by your physician, this is a great supplement to boost your production of dopamine, norepinephrine and epinephrine.
A powder made from the seeds of the leguminous plant, Mucuna pruriens has long been used in traditional Ayurvedic Indian medicine to stabilize mood and enhance cognition. It is also been used in the treatment of for diseases such as Parkinson’sParkison’s Disease, which is characterized by severe depletion of dopamine.
Dopamine is a chemical that cannot cross the blood-brain barrier, so cannot be directly supplemented as it would never reach the brain from the intestinal tract. For this reason, it is especially important to support our L-Dopa levels, to help dopamine synthesis in the brain.
Dopamine is a key neurotransmitter for muscul0ar-skeletal movement and reward-motivated behavior. So if you’ve struggled lately with feeling motivated to go to work for example, despite the reward of being paid for your effort, this powerful little neurotransmitter can help you with getting your ‘game face’ on!
Some studies on the role of Mucuna Pruriens and L-Tyrosine:
- Colzato, L. S; de Haan, A. M; Hommel, B. Food for creativity: tyrosine promotes deep thinking. Psychological Research September 2015, Volume 79, Issue 5, pp 709–714. https://link.springer.com/article/10.1007/s00426-014-0610-4
- Jongkees, B. J; Hommel, B; Kuhn, S; Colzato, L. S. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A review. Journal of Psychiatric Research Volume 70, November 2015, Pages 50-57. https://www.sciencedirect.com/science/article/pii/S0022395615002472
- Katzenschlager, R; Evans, A; Manson, A, et al, 2004. Mucuna pruriens in Parkinson’s disease: a double blind clinical and pharmacological study Journal of Neurology, Neurosurgery & Psychiatry 2004;75:1672-1677. https://jnnp.bmj.com/content/75/12/1672
- Kennedy, D. O; Wightman, E. L; Joanne, F; et al, 2017. Cognitive and Mood Effects of a Nutrient Enriched Breakfast Bar in Healthy Adults: A Randomised, Double-Blind, Placebo-Controlled, Parallel Groups Study. Nutrients 2017, 9(12), 1332; https://doi.org/10.3390/nu9121332
D,L-Phenylalanine (contraindicated for phenylketonuria, pregnant or breastfeeding women)
An essential amino acid, phenylalanine is the chemical precursor to tyrosine, another amino acid used in the production of neurotransmitters, and for balancing the thyroid.
Phenylalanine is essential for clear thinking, focus, mental alertness, physical energy, memory, and healthy appetite.
Very low levels of phenylalanine can lead to behavioral changes, eye disorders, poor vascular health, increase in appetite and weight gain.
Please note that phenylalanine is a powerful amino acid. It is great for you when used appropriately, but please do not exceed the dose stated on the bottle.
Some studies on the effects of Phenylalanine:
- Felger, J. C. and Treadway, M. T. Inflammation Effects on Motivation and Motor Activity: Role of Dopamine. Neuropsychopharmacology volume42, pages216–241 (2017). https://www.nature.com/articles/npp2016143
- Hufner, k; Oberguggenberger, A; Kohl, C. et al, 2015. Levels in neurotransmitter precursor amino acids correlate with mental health in patients with breast cancer. Psychoneuroendocrinology, Volume 60, October 2015, Pages 28-38. https://www.sciencedirect.com/science/article/pii/S030645301500205X
- Huijbregts, J. R; de Sonneville, S. C. J; van der Meere, L. M. J. et al, 2017. Cognitive profile and mental health in adult phenylketonuria: A PKU-COBESO study. Neuropsychology, Vol 31(4), May 2017, 437-447. http://psycnet.apa.org/buy/2017-12251-001
This herb is adaptogenic, meaning your body puts it to use where it is most needed. Rhodiola is most commonly taken for anxiety, stress and fatigue.
Early research suggests that Rhodiola is highly neuroprotective and can enhance cognitive function while reducing the negative effects of aging on the brain.
As well as fighting mental fatigue, this powerful herb is used to aid recovery from exercise. It has been suggested that Rhodiola Rosea may also have anti-cancer properties, although it is early days in terms of studies.
Some studies on the role of Rhodiola Rosea:
- Darbinyan, V; Kteyan, A; Panossian, E; Gabrielian, E; Wikman, G; Wagner, H. Rhodiola rosea in stress induced fatigue – A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine, Vol. 7(5), pp. 365–371. Download the PDF of the study.
- De Bock, K; Eijnde, B. O; Ramaekers, M; Hespel, P. Acute Rhodiola Rosea Intake Can Improve Endurance Exercise Performance. Sports Nutrition and Exercise Metabolism. Volume 14 Issue 3, June 2004.
- Spasov, A. A; Wikman, G. K; Mandrikov, V. B; Mironova, I. A, Neumoin, V. V. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine, Vol. 7(2), pp. 85–89.